Biomarker Discovery

biomarker discovery

Our innovative Biomarker Discovery program makes us a preferred partner for our pharmaceutical clients looking to identify novel targets for targeted therapies in pre-clinical development.

We have a long history of partnering with pharmaceutical companies to improve the clinical development process through discovery of novel markers and validation in tumor samples and cell lines.

We focus on:

  • Biomarker discovery for drugs in development, looking for:

  • Predictive biomarkers: drug response / intent to treat

  • Prognostic biomarkers: natural history of the disease

In-house and through partnerships we perform comprehensive pathology, molecular biology, in vitro and in vivo techniques:

  • Mutation analysis in tumor tissue and blood

  • Gene amplification and translocation testing

  • Immunohistochemistry (IHC)

  • Gene expression

  • MTT proliferation assays

  • Western blotting

  • Colony formation, migration and invasion assays

  • Molecular profiling of cell lines and tissue samples

  • Gene silencing

We have the capacity to work with formalin-fixed paraffin-embedded tumor tissue, fresh frozen samples, serum, plasma, platelets, and cytologies.
 
For further details of our biomarker discovery services: Contact us

 




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