Biomarker Discovery

Our innovative Biomarker Discovery program makes us a preferred partner for our pharmaceutical clients looking to identify novel targets for targeted therapies in pre-clinical development.

We have a long history of partnering with pharmaceutical companies to improve the clinical development process through discovery of novel markers and validation in tumor samples and cell lines.

We focus on:

• Biomarker discovery for drugs in development, looking for:

• Predictive biomarkers: drug response / intent to treat

• Prognostic biomarkers: natural history of the disease

In-house and through partnerships we perform comprehensive pathology, molecular biology, in vitro and in vivo techniques:

• Mutation analysis in tumor tissue and blood

• Gene amplification and translocation testing

• Immunohistochemistry (IHC)

• Gene expression

• MTT proliferation assays

• Western blotting

• Colony formation, migration and invasion assays

• Molecular profiling of cell lines and tissue samples

• Gene silencing

We have the capacity to work with formalin-fixed paraffin-embedded tumor tissue, fresh frozen samples, serum, plasma, platelets, and cytologies.
 
For further details of our biomarker discovery services: Contact us